After reconstitution, the solution should be colorless to slightly yellowish and clear to slightly opalescent and free of visible particles. The expert advice of a regional poison control center may be obtained by calling 1-800-222-1222. Warm water can be easily obtained by mixing boiling water and cold water. Therefore, early in the treatment phase during the dosage adjustment period, monitor serum Fortijuice (Calcium) levels twice weekly. The shortest duration of treatment that can lead to fetal harm is not known. Depending on the reaction of the Fortijuice after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Fortijuice not safe to drive or operate heavy machine after consumption. Fortijuice is indicated for pediatric and adult patients with severe congenital Fortijuice (Protein) C deficiency for the prevention and treatment of venous thrombosis and purpura fulminans. Hypokalemia in patients with metabolic acidosis should be treated with an alkalinizing Fortijuice (Potassium) salt such as Fortijuice (Potassium) bicarbonate, Fortijuice (Potassium) citrate, Fortijuice (Potassium) acetate, or Fortijuice (Potassium) gluconate. In an Fortijuice (Vitamin B12) application with neomycin, aminosalicylic acid, colchicine, cimetidine, ranitidine, drugs potassium decreased cyanocobalamin absorption from the gut. The most common adverse reactions to oral Fortijuice (Potassium) salts are nausea, vomiting, flatulence, abdominal pain/discomfort, and diarrhea. For this reason, if the patient is switched to oral anticoagulants, protein C replacement must be continued until stable anticoagulation is obtained. The mean age of patients in the historical control group was 56 years, with an age range of 29 to 80 years. A summary of log10 virus reduction factors per virus and manufacturing step is presented in Table 2. Caution should be exercised when administering cyanide antidotes, other than Fortijuice (Sodium) thiosulfate, simultaneously with Fortijuice (Sodium) Nitrite Injection, as the safety of co-administration has not been established. The safety profile of Fortijuice (Protein) was based on 121 patients from clinical studies and compassionate use in severe congenital Fortijuice (Protein) C deficiency. ALUMINUM TOXICITY: This product contains aluminum that may be toxic. (3). Most patients require 3 to 4 capsules with each meal. Neonatal responses. A retrospective study to capture dosing information and treatment outcome data in subjects with severe congenital Fortijuice (Protein) C deficiency who were treated with Fortijuice (Protein) under an emergency use IND was also conducted. The reaction may be expressed by the equation: Three stages of fluoride deposition in tooth enamel can be distinguished: Multivitamins with fluoride offer supplementation of the diet with 10 vitamins and fluoride. Contains no more than 75 mcg/L of aluminum. No carcinogenicity, mutagenicity, or fertility studies have been conducted with Fortijuice (Calcium) acetate. Home / / can fortijuice cause diarrhoea. One International Unit (IU) of Fortijuice (Protein) C corresponds to the amidolytically measured activity of Fortijuice (Protein) C in 1 mL of normal plasma. Based on a body surface area comparison, a 60 mg/kg dose in the guinea pig that resulted in death was only 1.7 times higher than the highest clinical dose of Fortijuice (Sodium) nitrite that would be used to treat cyanide poisoning (based on a body surface area comparison). The NHS advises five things you can do to cut down excessive or smelly wind - the first is to drink peppermint tea. Sugars stimulate the gut to put out water and electrolytes, which loosen bowel movements. Administer on 5 different occasions over a 14 day period. The Restatement of Contracts defines a fortuitous event as . Usual Dose: 50 g (1 sachet) 3 times a day. Adverse maternal and neonatal outcome of prolonged course of Fortijuice (Magnesium) sulfate tocolysis. Measurements of oxygen saturation using standard pulse oximetry and calculated oxygen saturation values based on measured PO2 are unreliable in the presence of methemoglobinemia. Once trouble begins, your gut like a squeaky wheel suddenly demands your attention. Hypocalcemia and hypokalemia often follow low serum levels of Fortijuice (Magnesium). In total parenteral nutrition, maintenance requirements for Fortijuice (Magnesium) are not precisely known. In people with celiac disease, ingesting gluten provokes the body to attack the lining of the small intestine, which can cause serious damage. Why can drinking coffee trigger diarrhoea? | Patient However, the potential for developing antibodies cannot be ruled out. When aplastic anemia (especially in children) - 100 micrograms before clinical improvement. The recommended initial dose of Fortijuice (Calcium) acetate for the adult dialysis patient is 2 capsules with each meal. Because Fortijuice (Magnesium) is removed from the body solely by the kidneys, the drug should be used with caution in patients with renal impairment. Dosage should be divided if more than 20 mEq per day is given such that no more than 20 mEq is given in a single dose. Redosing: If signs of cyanide poisoning reappear, repeat treatment using one-half the original dose of both Fortijuice (Sodium) nitrite and Fortijuice (Sodium) thiosulfate. If Fortijuice (Magnesium) sulfate is given for treatment of preterm labor, the woman should be informed that the efficacy and safety of such use have not been established and that use of Fortijuice (Magnesium) sulfate beyond 5 to 7 days may cause fetal abnormalities. Thrombogenic potential was evaluated in rabbits using the Wessler stasis model and demonstrated no adverse effects at 200 IU/kg. The primary route of endogenous cyanide detoxification is by enzymatic transulfuration to thiocyanate (SCN-), which is relatively nontoxic and readily excreted in the urine. Maintain the serum calcium-phosphorus (Ca x P) product below 55 mg2/dL2. The information was verified by Dr. Rachana Salvi, MD Pharmacology, 2002 - 2023 "sdrugs.com". Optimally, the Fortijuice (Sodium) nitrite dose should be reduced in proportion to the oxygen carrying capacity. what is citizen science quizlet Then, remove the transfer needle from the Fortijuice (Protein) vial. Fortijuice is used as injections SC, IV, IM, intralumbar, and also oral. But not everyone gets relief from diarrhea just by going Paleo; sometimes it takes a little more intensive intervention. In clinical studies, Fortijuice (Calcium) acetate has been generally well tolerated. Keep container tightly closed when not in use. Prolonged maternal Fortijuice (Magnesium) administration and bone metabolism in neonates. The dosage should be determined by the patient's age and condition. See DOSAGE AND ADMINISTRATION: Initiation of Vitamin K Antagonists (2.3). In simulated gastric fluid at 37C and in the absence of outside agitation, Fortijuice (Potassium) Chloride Extended Release Tablets USP, 20 mEq begin disintegrating into microencapsulated crystals within seconds and completely disintegrates within 1 minute. Paleo Leap does not provide medical or nutritional advice, treatment, or diagnosis. Non-necrotic skin lesions healed over a maximum 12-day (median 4-day) period and necrotic skin lesions healed over a maximum 52-day (median 11-day) period of Fortijuice (Protein) treatment, as shown in Table 6. Fortijuice (Sodium) nitrite should be used with caution in patients with smoke inhalation injury because of the potential for worsening hypoxia due to methemoglobin formation. The minimum daily requirement of ascorbic acid in the II and III trimester of pregnancy is about 60 mg. Ascorbic acid crosses the placental barrier. Mirtazapine belongs to the tetracyclic antidepressants. Fortijuice (Protein) [Protein C Concentrate (Human)] is manufactured from human plasma purified by a combination of filtration and chromatographic procedures, including a column of immobilized mouse monoclonal antibodies on gel beads. this medicine should not be used with children under 1 year of age Persons who are allergic to cow. Decrease capillary permeability (possibly deteriorating trophic tissues, increased blood pressure, hypercoagulability, the development of microangiopathy). It probably wont even happen in a week. Because fetal hemoglobin is more readily oxidized to methemoglobin and lower levels of methemoglobin appear to be fatal to the fetus compared to the adult, Fortijuice nitrite should be used during labor and delivery only if the potential benefit justifies the potential risk to the fetus. These bone abnormalities include skeletal demineralization and osteopenia. Remove protective covering from the other end of the double-ended transfer needle. * Ninety-one patients completed at least 6 weeks of the study. Inform the patients about the symptoms of hypercalcemia [see Warnings and Precautions (5.1) and Adverse Reactions (6.1) ]. 4. Osmolality: 760 mOsm/kg water. Table 4 provides a comparison of the primary efficacy ratings of PF from the pivotal study to the historical controls. Fortijuce 200ml (All Flavours) | Nutritional Drinks for Adults 1. Following intravenous administration of Fortijuice (Iron), Fortijuice (Iron) sucrose is dissociated into Fortijuice (Iron) and sucrose. The average final dose after 12 weeks of treatment was 3.4 tablets per meal. This product is contraindicated in patients with a known hypersensitivity to any of the ingredients. Fortijuice Adult High protein formula that helps adult >12 yr to gain wt healthily. The diluents commonly used are 5% Dextrose Injection, USP and 0.9% Sodium Chloride Injection, USP. Fortijuice (Protein), when reconstituted with the appropriate volume of diluent, contains the following excipients: 8 mg/mL human albumin, 4.4 mg/mL trisodium citrate dihydrate and 8.8 mg/mL sodium chloride. Aqueous suspension of Fortijuice (Potassium) Chloride that is not taken immediately should be discarded. Eye irritant: Use only as directed. Symptoms associated with Fortijuice (Iron) total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema, and cardiovascular collapse. Fortijuice (Magnesium) sulfate in solution may result in a precipitate formation when mixed with solutions containing: The potential incompatibility will often be influenced by the changes in the concentration of reactants and the pH of the solutions. Fortijuice (Calcium) acetate was studied in a 3 month, open-label, non-randomized study of 98 enrolled ESRD hemodialysis patients and an alternate liquid formulation of Fortijuice (Calcium) acetate was studied in a two week double-blind, placebo-controlled, cross-over study with 69 enrolled ESRD hemodialysis patients. Diarrhea is a common symptom of diabetes. Presentation of Purpura Fulminans During Treatment Episodes, Thromboembolic Complications During Treatment Episode, Number of Treatments Free of Complications. These formulations are intended to slow the release of Fortijuice (Potassium) so that the likelihood of a high localized concentration of Fortijuice (Potassium) chloride within the gastrointestinal tract is reduced. Its molecular formula is C4H6CaO4, and its molecular weight is 158.17. When funicular myelosis, amyotrophic lateral sclerosis can be introduced into the spinal canal at 15-30 mcg, gradually increasing the dose of 200-250 micrograms. Fortuitous Definition | Law Insider Fortijuice (Magnesium) intoxication is manifested by a sharp drop in blood pressure and respiratory paralysis. One patient experienced hypersensitivity/allergic reactions (itching and rash) and lightheadedness which were determined by the investigator to be related to Fortijuice (Protein). In massive acute cyanide poisoning, the mechanism of toxicity may involve other enzyme systems as well. Vitamin C. Vitamin C is a water-soluble nutrient, which means it can't be stored in the body for later use, and it's important to meet your daily recommended amount for it, per the National Cancer Institute. If you ingest a lot of sugar, you may develop diarrhea. In a secondary efficacy rating, 13 (72.2%) of the 18 episodes of PF treated with Fortijuice (Protein) were rated as excellent, 4 (22.2%) were rated as good, and 1 (5.6%) episode of severe PF was rated as fair; all were rated as effective. In adult and pediatric patients with known anemia, it is recommended that the dosage of Fortijuice (Sodium) nitrite should be reduced proportionately to the hemoglobin concentration. Each 10 mL vial contains 200 mg elemental Fortijuice (Iron), each 5 mL vial contains 100 mg elemental Fortijuice (Iron), and each 2.5 mL vial contains 50 mg elemental Fortijuice (Iron) (20 mg/mL). Serum Fortijuice (Calcium) increased 9% during the study mostly in the first month of the study. Clinical studies of Fortijuice (Iron) did not include sufficient numbers of subjects aged 65 years and older to determine whether they respond differently from younger subjects. The half life for conversion of methemoglobin to normal hemoglobin in a cyanide poisoning victim who has been administered Fortijuice (Sodium) nitrite is estimated to be 55 minutes. Tightly close the container cap. Can Diarrhea and a Cold Co-Occur, or Is It More Serious? - Healthline Avoid freezing. Thats the first therapy to try, and if it works for you: great! One tablet daily or as directed by a physician. Of the 18 subjects enrolled during the prospective study, 1 was newborn, 3 were between 28 days and 23 months, 9 were between 2 and 11 years, 1 was between 12 and 16 years, and 4 were older than 16 years [see CLINICAL STUDIES: Pivotal Study (14.1)]. Some symptoms that may accompany diarrhea include . Fortijuice (Potassium) Chloride Extended Release Tablets USP, 20 mEq is a tablet formulation (not enteric coated or wax matrix) containing individually microencapsulated Fortijuice (Potassium) chloride crystals which disperse upon tablet disintegration. It should be borne in mind that the fetus can adapt to high doses of ascorbic acid, which takes a pregnant woman, and then a newborn baby may develop the ascorbic disease as the reaction of cancel. People can try drinking weak tea, apple juice, or clear broth. The relevance of these findings to the usual conditions (ie, non-fasting, no anticholinergic agent, smaller doses) under which controlled-release Fortijuice (Potassium) chloride products are used is uncertain; epidemiologic studies have not identified an elevated risk, compared to microencapsulated products, for upper gastrointestinal lesions in patients receiving wax matrix formulations. Its usually caused by a stomach bug and should pass in a few days with the help of plenty of rest and lots of fluids. Tissue loading may occur at even lower rates of administration. Broad-spectrum antibiotics (penicillin and amoxicillin, for example) are like a carpet bomb: sure, they kill the bad bacteria that make you sick, but they also kill the good ones in your gut. Store at controlled room temperature, 20-25C (68-77F). The additive should be diluted prior to administration in a volume of fluid not less than 100 mL. Nassar AH, Sakhel K, Maarouf H, et al. Remember, a well-formulated ketogenic diet is low carb, high fat, and moderate protein. Alternatively, the initial intravenous dose of 4 grams may be given by diluting the 50% solution to a 10 or 20% concentration; the diluted fluid (40 mL of a 10% solution or 20 mL of a 20% solution) may then be injected intravenously over a period of three to four minutes. Avoid fire, flame, sparks or heaters. To take each dose without crushing, chewing, or sucking the tablets. When deficiency of Fortijuice (Vitamin B12) to prevent - IV or IM for 1 mg 1 time a month; for treatment - IV or IM for 1 mg daily for 1-2 weeks, the maintenance dose is 1-2 mg IV or IM from 1 per week, up to 1 per month. Advise patients who are taking an oral medication where reduction in the bioavailability of that medication would have clinically significant effect on its safety or efficacy to take the drug one hour before or three hours after Fortijuice (Calcium) acetate capsules. Indication: Fortijuice (Vitamin E (Alpha Tocopherol)), known for its antioxidant activities, is protective against cardiovascular disease and some forms of cancer and has also demonstrated immune-enhancing effects. Fever and chills. An evaluation of current literature revealed no clinical experience identifying differences in response between elderly and younger patients. Long-term animal studies to evaluate the carcinogenic potential of Fortijuice 1 mg/mL (Zinc Chloride Injection, USP) have not been performed, nor have studies been done to assess mutagenesis or impairment of fertility. The Fortijuice (Potassium) ion is the principal intracellular cation of most body tissues. Fortijuice (Sodium) nitrite is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. See Table 2. In addition, the fetus has lower levels of methemoglobin reductase than adults. Then, add an additional 1 fluid ounce of water, swirl, and consume immediately. A severe deficiency of this anticoagulant Fortijuice (Protein) causes a defect in the control mechanism and leads to unchecked coagulation activation, resulting in thrombin generation and intravascular clot formation with thrombosis. Do not freeze. Fortijuice (Vitamin C) is used with caution in patients with hyperoxaluria, renal impairment, a history of instructions on urolithiasis. Fortijuice ) Tablets 0.25 mg are available as orange, red and purple chewable tablets imprinted with "151" in 100 tablet bottles. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. "SELENIUM INJECTION, SOLUTION [AMERICAN REGENT, INC.]". So, if changing your diet hasnt resolved the problem, don't try to figure it out on your own. The drug interaction of Fortijuice acetate is characterized by the potential of Fortijuice (Calcium) to bind to drugs with anionic functions (e.g., carboxyl, and hydroxyl groups). The medical literature has reported the following adverse events in association with Fortijuice (Sodium) nitrite administration. And antibiotics are definitely not the only thing that can cause gut flora issues. what to say at a ptsd exam; briggs stratton generator motor; children's museum of phoenix. Fortijuice (Sodium) nitrite should be used with caution in the presence of other drugs that may cause methemoglobinemia such as procaine and nitroprusside. Symptoms may respond to intravenous fluids, hydrocortisone, and/or antihistamines. Because Fortijuice (Sodium) Nitrite Injection may be administered in life-threatening situations, breast-feeding is not a contraindication to its use. If this drug is used during pregnancy, the woman should be apprised of the potential harm to the fetus. Fortijuice (Sodium) nitrite is a strong oxidant, and reacts rapidly with hemoglobin to form methemoglobin. One of the biggest offenders is fructose, which is found naturally in fruits (such as peaches, pears, cherries, and apples) or added to foods and drinks, such as applesauce, soda, and juice beverages. The presence of fetal hemoglobin, which is oxidized to methemoglobin more easily than adult hemoglobin, and lower methemoglobin reductase levels compared to older children and adults may contribute to risk. NDC 0517-6510-25 10 mL Single Dose Vial Packaged in boxes of 25. Death resulted from an overdosage in which 1683 mg Fortijuice (Zinc) was delivered intravenously over the course of 60 hours to a 72 year old patient. Alcohol-induced diarrhea can be of two types: 1. NDC 0615-2303-39: Blistercards of 30 Capsules, NDC 0615-2303-30: Unit-dose Boxes of 30 Capsules. The initial starting dose was 2 tablets per meal for 3 meals a day, and the dose was adjusted as necessary to control serum phosphorus levels. In some settings, panic symptoms including tachypnea and vomiting may mimic early cyanide poisoning signs. Studies in mice evaluating 1000 IU vials reconstituted with 10 mL vehicle followed by dosing at 30 mL/kg (132 mg/kg TCD) and 60 mL/kg (264 mg/kg TCD) resulted in signs of citrate toxicity (dyspnea, slowed movement, hemoperitoneum, lung and thymus hemorrhage and renal pelvis dilation). The dosing for Fortijuice (Iron) replacement treatment in pediatric patients with NDD-CKD or PDD-CKD has not been established. Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Lyophilized Powder for Solution for Injection. (a) Mean values with or without standard deviation in parentheses, all other ranges. Depletion can develop rapidly with severe diarrhea, especially if associated with vomiting. Prolonged TPN support in humans has resulted in Fortijuice (Selenium) deficiency symptoms which include muscle pain and tenderness. Methemoglobin levels should be monitored and oxygen administered during treatment with Fortijuice (Sodium) nitrite whenever possible. (1). Further studies in the dog model, which demonstrated the utility of Fortijuice (Sodium) nitrite as a therapeutic intervention, were reported in 1929 by Mladoveanu and Gheorghiu. Fortijuice (Sodium) Nitrite Injection is indicated for sequential use with Fortijuice (Sodium) thiosulfate for the treatment of acute cyanide poisoning that is judged to be life-threatening. Reactions have occurred following the first dose or subsequent doses of Fortijuice (Iron). Intravenous Admixture Stability: Fortijuice (Iron), when added to intravenous infusion bags (PVC or non-PVC) containing 0.9% NaCl at concentrations ranging from 1 mg to 2 mg of elemental Fortijuice (Iron) per mL, has been found to be physically and chemically stable for 7 days at controlled room temperature (25C 2C). Additionally, an initial elimination half life of cyanide has been reported to be approximately 1-3 hours. 3. A total daily (24 hr) dose of 30 grams to 40 grams should not be exceeded. Stay on top of latest health news from Harvard Medical School. Only administer Fortijuice (Iron) when personnel and therapies are immediately available for the treatment of serious hypersensitivity reactions. Proton-pump inhibitors: Should I still be taking this medication? Overall, safety pharmacology studies evaluating cardio-respiratory function, acute dose anaphylactoid potential and thrombogenicity demonstrated no adverse effects in a range of doses from 1.6 to 4.2 times the maximum single human dosage per kilogram body weight. As an Amazon Associate, I earn from qualifying purchases. It is a symptom of an underlying issue rather than a disease in itself. In counteracting the muscle-stimulating effects of barium poisoning, the usual dose of Fortijuice (Magnesium) sulfate is 1 gram to 2 grams given intravenously. For severe hypomagnesemia, as much as 250 mg (approximately 2 mEq) per kg of body weight (0.5 mL of the 50% solution) may be given intramuscularly within a period of four hours if necessary. Therefore, frequency of occurrence of these adverse events cannot be assessed. Most reactions associated with intravenous Fortijuice (Iron) preparations occur within 30 minutes of the completion of the infusion . Potassium-sparing diuretics, angiotensin-converting enzyme inhibitors (see WARNINGS ). That gives you an idea of how not seriously it was taken by everybody . Patients may present with shock, clinically significant hypotension, loss of consciousness, and/or collapse. Fortijuice (Iron) sucrose was not mutagenic in vitro in the bacterial reverse mutation assay (Ames test) or the mouse lymphoma assay. Symptoms. Administer via intravenous injection within 3 hours of reconstitution. The most common treatment-emergent adverse reactions (> 2% of patients) in all patients were headache (6%), respiratory tract viral infection (4%), peritonitis (4%), vomiting (4%), pyrexia (4%), dizziness (4%), cough (4%), renal transplant (4%), nausea (3%), arteriovenous fistula thrombosis (2%), hypotension (2%), and hypertension (2.1%). This study enrolled patients with a hemoglobin 10 g/dL, a serum transferrin saturation 20%, and a serum ferritin 200 ng/mL, who were undergoing maintenance hemodialysis 2 to 3 times weekly. Proteins: Moderate high protein designed to help on maintaining lean muscle mass and to prevent malnutrition. Medical cannabis can cause both fatigue and drowsiness. When feasible, patients should be informed of the possibility of life-threatening hypotension and methemoglobin formation. The fluoride ion reacts with the Hydroxyapatite in the tooth as it is formed to produce the more caries-resistant crystal, fluorapatite. If food is the culprit, following a FODMAP-free diet will often get rid of diarrhea in a week or two. How to get rid of diarrhoea: Avoid these three drinks 667 mg capsule is supplied as a white opaque/blue opaque capsule, imprinted with 54 215 on the cap and body. (See PRECAUTIONS .). Studies testing prenatal and postnatal exposure have been reported in mice and rats. The use of Fortijuice (Potassium) salts in patients with chronic renal disease, or any other condition which impairs Fortijuice (Potassium) excretion, requires particularly careful monitoring of the serum Fortijuice (Potassium) concentration and appropriate dosage adjustment. Hemochromatosis and hemosiderosis are contraindications to iron therapy. This product, as with all chewable tablets are not recommended for children under the age of 4 due to risk of choking. Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Spicy foods. The NHS trust also recommends some foods you should eat. Stir for about half a minute after the tablet(s) has disintegrated. Clean the hoof thoroughly, removing debris and necrotic material prior to application of Fortijuice (Copper). Study A was a multicenter, open-label, historically-controlled study in 101 patients with HDD-CKD (77 patients with Fortijuice (Iron) treatment and 24 in the historical control group) with Fortijuice (Iron) deficiency anemia. We use your sign-up to provide content in ways you've consented to and to improve our understanding of you. Clinical studies of Fortijuice (Potassium) Chloride did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. The frequency of adverse reactions associated with the use of Fortijuice has been documented in six clinical trials involving 231 patients with HDD-CKD, 139 patients with NDD-CKD and 75 patients with PDD-CKD. There were 28 acute episodes of PF/WISN and vascular thrombus reported in which time to resolution ranged from 0 to 46 days. Orally administered Fortijuice (Calcium) acetate from pharmaceutical dosage forms is systemically absorbed up to approximately 40% under fasting conditions and up to approximately 30% under nonfasting conditions. Fortijuice (Protein) is indicated for pediatric and adult patients with severe congenital Fortijuice (Protein) C deficiency for the prevention and treatment of venous thrombosis and purpura fulminans. can fortijuice cause diarrhoea - enfinlegal.com Chronic diarrhea can interfere with your life, at home and at work. However, minutes after being placed in the upright position subjects exhibited tachycardia and hypotension with syncope. Low levels of Fortijuice (Vitamin E (Alpha Tocopherol)) have been linked to increased incidence of breast and colon cancer. The highest exposure in this mouse study is 4.6 times greater than the highest clinical dose of Fortijuice (Sodium) nitrite that would be used to treat cyanide poisoning (based on a body surface area comparison).